Cut 4 ¼ inch slices of the scrapple and lay on a clean paper towel (this helps remove moisture).
In a large bowl, mix the Wondra flour, garlic powder, onion powder, cayenne, salt and pepper and mix well, set aside.
In a 10” cast iron skillet, heat the bacon grease and butter until hot and a drop of water spatters enthusiastically.
While the pan is heating, very carefully dredge the scrapple slices in the wondra flour. Pat the flour into the scrapple gently.
Lay each piece of scrapple into the hot oil after it is dredged in the flour. Fry as many as 3-4 at a time.
Cook for 3 minutes per side without disturbing during cooking, turn the pieces very gently.
Remove to a clean paper towel to drain.